Midazolam effects on prepulse inhibition of the acoustic blink reflex
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چکیده
منابع مشابه
Effects of early acoustic stimulation on prepulse inhibition in mice
The purpose of this study was to determine the effects of an atypical pattern of early acoustic stimulation on auditory development. Previous human research suggests that the acoustic environment of pre-term human infants in the Neonatal Intensive Care Unit (NICU) negatively affects some aspects of auditory development. Animal research suggests that premature auditory stimulation interrupts aud...
متن کاملReflex excitability regulates prepulse inhibition.
Presentation of a weak stimulus, a prepulse, before a reflex-evoking stimulus decreases the amplitude of the reflex response relative to reflex amplitude evoked without a preceding prepulse. For example, presenting a brief tone before a trigeminal blink-eliciting stimulus significantly reduces reflex blink amplitude. A common explanation of such data are that sensory processing of the prepulse ...
متن کاملLesions of the paraventricular thalamic nucleus attenuates prepulse inhibition of the acoustic startle reflex.
The paraventricular thalamic nucleus (PVT) is a midline nucleus with strong connections to cortical and subcortical brain regions such as the prefrontal cortex, amygdala, nucleus accumbens and hippocampus and receives strong projections from brain stem nuclei. Prepulse inhibition (PPI) is mediated and modulated by complex cortical and subcortical networks that are yet to be fully identified in ...
متن کاملPrepulse Inhibition of Acoustic Startle Reflex as a Function of the Frequency Difference between Prepulse and Background Sounds in Mice
BACKGROUND Prepulse inhibition (PPI) depicts the effects of a weak sound preceding strong acoustic stimulus on acoustic startle response (ASR). Previous studies suggest that PPI is influenced by physical parameters of prepulse sound such as intensity and preceding time. The present study characterizes the impact of prepulse tone frequency on PPI. METHODS Seven female C57BL mice were used in t...
متن کاملBackground noise decreases both prepulse elicitation and inhibition of acoustic startle blink responding.
Prepulse inhibition of startle (PPI) has proved to be useful in distinguishing between schizophrenia patients and normal controls, although not all studies in this area find such group differences. One reason for this inconsistency may be the fact that some research labs present the startle eliciting and inhibiting stimuli over a steady background noise (70 dB), whereas others present stimuli i...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1999
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.1999.00896.x